Entrepreneur Isaac Tigrett started hearing voices in his head when he was a teenager. "I have been intuitive since I was about 14 or 15," he says. "Somebody died in my arms, and I went into trauma shock and something happened to my psyche. Suddenly things out of my own consciousness started coming into my mind. I thought I was crazy."

Given Tigrett's subsequent career, the 45-year-old founder and former CEO of the Hard Rock Cafe's early doubts about his sanity seem unfounded. By alternatin...